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Issue 30, 2017
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The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

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Abstract

Metalation of hen egg white lysozyme (HEWL) with organometallics was studied with physicochemical methods in solid state, solution and the gas phase. While metalation did not affect the crystal structure of HEWL significantly, protein destabilisation was detected in gas phase and solution.

Graphical abstract: The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

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Publication details

The article was received on 22 Dec 2016, accepted on 16 Mar 2017 and first published on 21 Mar 2017


Article type: Communication
DOI: 10.1039/C6CC10150J
Chem. Commun., 2017,53, 4246-4249

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    The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

    M. P. Sullivan, M. Groessl, S. M. Meier, R. L. Kingston, D. C. Goldstone and C. G. Hartinger, Chem. Commun., 2017, 53, 4246
    DOI: 10.1039/C6CC10150J

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