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Issue 6, 2017
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Silver-catalysed tandem hydroamination and cyclization of 2-trifluoromethyl-1,3-enynes with primary amines: modular entry to 4-trifluoromethyl-3-pyrrolines

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Abstract

A highly efficient tandem hydroamination and cyclization reaction of 2-trifluoromethyl-1,3-enynes with primary amines leading to 4-trifluoromethyl-3-pyrrolines was developed by using AgNO3 as a catalyst under mild reaction conditions. This new method is compatible with alkyl, aryl, and allyl primary amines, representing an atom-economical protocol for the construction of 4-trifluoromethyl-3-pyrrolines for the first time.

Graphical abstract: Silver-catalysed tandem hydroamination and cyclization of 2-trifluoromethyl-1,3-enynes with primary amines: modular entry to 4-trifluoromethyl-3-pyrrolines

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Publication details

The article was received on 02 Dec 2016, accepted on 19 Dec 2016 and first published on 19 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC09595J
Chem. Commun., 2017,53, 1084-1087

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    Silver-catalysed tandem hydroamination and cyclization of 2-trifluoromethyl-1,3-enynes with primary amines: modular entry to 4-trifluoromethyl-3-pyrrolines

    X. Zhou, C. Huang, Y. Zeng, J. Xiong, Y. Xiao and J. Zhang, Chem. Commun., 2017, 53, 1084
    DOI: 10.1039/C6CC09595J

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