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Issue 8, 2017
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Direct enantioselective C-acylation for the construction of a quaternary stereocenter catalyzed by a chiral bicyclic imidazole

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Abstract

A direct enantioselective C-acylation of 3-substituted benzofuran-2(3H)-ones (with up to 97% ee) was developed using a chiral bicyclic imidazole catalyst OAc-DPI and an achiral tertiary amine additive DIPEA. The reaction mechanism for the direct C-acylation has been investigated using both experimental and theoretical studies.

Graphical abstract: Direct enantioselective C-acylation for the construction of a quaternary stereocenter catalyzed by a chiral bicyclic imidazole

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Article information


Submitted
27 Nov 2016
Accepted
03 Jan 2017
First published
03 Jan 2017

Chem. Commun., 2017,53, 1381-1384
Article type
Communication

Direct enantioselective C-acylation for the construction of a quaternary stereocenter catalyzed by a chiral bicyclic imidazole

M. Wang, X. Zhang, Z. Ling, Z. Zhang and W. Zhang, Chem. Commun., 2017, 53, 1381
DOI: 10.1039/C6CC09451A

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