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Issue 8, 2017
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Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

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Abstract

We report the synthesis of a 5-formyl-2′-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.

Graphical abstract: Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

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Article information


Submitted
28 Oct 2016
Accepted
28 Dec 2016
First published
04 Jan 2017

This article is Open Access

Chem. Commun., 2017,53, 1389-1392
Article type
Communication

Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

F. Kawasaki, P. Murat, Z. Li, T. Santner and S. Balasubramanian, Chem. Commun., 2017, 53, 1389
DOI: 10.1039/C6CC08670E

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