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Issue 8, 2017
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Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications

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Abstract

Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.

Graphical abstract: Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications

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Supplementary files

Article information


Submitted
14 Oct 2016
Accepted
01 Dec 2016
First published
01 Dec 2016

Chem. Commun., 2017,53, 1366-1369
Article type
Communication

Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications

Q. Zhang, Q. Wang, S. Xu, L. Zuo, X. You and H. Hu, Chem. Commun., 2017, 53, 1366
DOI: 10.1039/C6CC08292K

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