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Issue 10, 2017
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Construction and characterisation of a heparan sulphate heptasaccharide microarray

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Abstract

A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.

Graphical abstract: Construction and characterisation of a heparan sulphate heptasaccharide microarray

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Publication details

The article was received on 11 Oct 2016, accepted on 03 Jan 2017 and first published on 11 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC08204A
Chem. Commun., 2017,53, 1743-1746

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    Construction and characterisation of a heparan sulphate heptasaccharide microarray

    J. Yang, P. Hsieh, X. Liu, W. Zhou, X. Zhang, J. Zhao, Y. Xu, F. Zhang, R. J. Linhardt and J. Liu, Chem. Commun., 2017, 53, 1743
    DOI: 10.1039/C6CC08204A

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