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Issue 2, 2017
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Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes

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Abstract

We demonstrate a novel system for inducing clustering of cell surface receptors via recognition peptide segments displayed on exosomes, leading to receptor activation. With this system, targeting of receptor-expressing cells and facilitation of the endocytic uptake of exosomes, which contained the anti-cancer protein saporin, were successfully achieved, leading to cell death.

Graphical abstract: Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes

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Supplementary files

Article information


Submitted
16 Aug 2016
Accepted
08 Nov 2016
First published
08 Nov 2016

Chem. Commun., 2017,53, 317-320
Article type
Communication

Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes

I. Nakase, N. Ueno, M. Katayama, K. Noguchi, T. Takatani-Nakase, N. B. Kobayashi, T. Yoshida, I. Fujii and S. Futaki, Chem. Commun., 2017, 53, 317
DOI: 10.1039/C6CC06719K

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