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Issue 9, 2017
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MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin

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Abstract

Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd(III)). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance.

Graphical abstract: MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin

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Article information


Submitted
15 May 2017
Accepted
12 Jun 2017
First published
13 Jun 2017

Biomater. Sci., 2017,5, 1746-1750
Article type
Communication

MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin

B. Wu, X. Li, T. Huang, S. Lu, B. Wan, R. Liao, Y. Li, A. Baidya, Q. Long and H. Xu, Biomater. Sci., 2017, 5, 1746
DOI: 10.1039/C7BM00431A

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