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Issue 9, 2017
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Impact of the biomolecular corona on the structure of PEGylated liposomes

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Abstract

Driven by the promises of gene therapy, PEGylated cationic liposomes (CLs) have been investigated for decades, but their use in the clinical setting is far from established. Such a dichotomy is due to several factors that have been ignored over the last two decades. The hardest challenge seems to occur when PEGylated CLs come into contact with a physiological environment (e.g. the blood). Recent evidence has demonstrated that PEGylation does not completely prevent protein binding (as believed so far), but a biomolecular shell, termed “biomolecular corona” (BC), covers the liposome surface. Here we show that the formation of a BC not only affects the surface properties of PEGylated CLs, but also, and significantly, their bilayer structure thus impairing their ability to safely deliver their cargo to the target site. Therefore, a mechanistic understanding of the structures emerging from liposome–protein interactions may represent a truly new paradigm for the clinical translation of PEGylated CLs.

Graphical abstract: Impact of the biomolecular corona on the structure of PEGylated liposomes

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Supplementary files

Article information


Submitted
27 Apr 2017
Accepted
14 Jun 2017
First published
19 Jun 2017

Biomater. Sci., 2017,5, 1884-1888
Article type
Paper

Impact of the biomolecular corona on the structure of PEGylated liposomes

L. Digiacomo, D. Pozzi, H. Amenitsch and G. Caracciolo, Biomater. Sci., 2017, 5, 1884 DOI: 10.1039/C7BM00387K

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