Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 41, 2016
Previous Article Next Article

Surfactant-free synthesis of a water-soluble PEGylated nanographeneoxide/metal-oxide nanocomposite as engineered antimicrobial weaponry

Author affiliations

Abstract

A global upsurge in antibiotic resistance has led to research in metal-based antimicrobial therapy. Nonetheless, the clinical translation of metal oxides is often hampered by their poor aqueous solubility. This work unravels the surfactant-free synthesis of a water-soluble PEGylated nanographene oxide/zinc-doped copper oxide complex (NGO-PEG–Zn–CuO) with superior antibacterial activity. We uncover its mechanism of bacterial cell death over E. coli and S. aureus associated with oxidative stress and high production of reactive oxygen species (ROS) compared to NGO–ZnCuO, ZnCuO and NGO-PEG. A simple, one-step sonochemical technique is employed to deposit the Zn–CuO nanoparticles (NPs) on NGO-PEG. This complex demonstrates excellent aqueous solubility in different physiological solutions, including serum. Moreover, it exhibits excellent stability in water for a period of more than two months with almost no cytotoxicity effect on HeLa cells. Taken together, these results display the superior potency of the NGO-PEG–ZnCuO complex as a soluble and non-toxic compound with enhanced antibacterial properties.

Graphical abstract: Surfactant-free synthesis of a water-soluble PEGylated nanographeneoxide/metal-oxide nanocomposite as engineered antimicrobial weaponry

Back to tab navigation

Supplementary files

Article information


Submitted
11 Jul 2016
Accepted
14 Sep 2016
First published
15 Sep 2016

J. Mater. Chem. B, 2016,4, 6706-6715
Article type
Paper

Surfactant-free synthesis of a water-soluble PEGylated nanographeneoxide/metal-oxide nanocomposite as engineered antimicrobial weaponry

R. K. Mishra, Y. Shalom, V. B. Kumar, J. H. T. Luong, A. Gedanken and E. Banin, J. Mater. Chem. B, 2016, 4, 6706
DOI: 10.1039/C6TB01728B

Social activity

Search articles by author

Spotlight

Advertisements