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Issue 32, 2016
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Biodegradable shape memory polymers functionalized with anti-biofouling interpenetrating polymer networks

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Abstract

A novel type of shape memory polyurethane (SMPU) with high mechanical properties and biodegradability was constructed using a lactone copolymer (poly(ε-caprolactone-co-γ-butyrolactone), PCLBL), a diol- or triol-based chain extender (1,5-pentanediol, glycerol and 2-amino-2-hydroxymethyl-1,3-propanediol) and a diisocyanate cross-linker (1,6-hexamethylene diisocyanate). All types of SMPUs possessed high mechanical properties, and the shape recovery test indicated that the SMPU sheets prepared using a triol-chain extender with an amine group recovered completely the original shape at 80 °C. Moreover, the degradation products of the SMPUs were innoxious, which is an important property for use in the biomedical field. Furthermore, the SMPU sheets were interpenetrated with a zwitterionic polymer, poly(carboxymethyl betaine) (PCMB), using the interpenetrating polymer network (IPN) method to additionally introduce an anti-biofouling property. Water contact angle measurements of the surface of PCMB-introduced SMPU sheets showed a drastic reduction from 87° to approximately 30° due to the exposure of the PCMB chains from the SMPU sheets. These SMPU-IPN sheets suppressed significantly both protein adsorption and cell adhesion. Consequently, the PCLBL-PU-based SMPUs interpenetrated with PCMB are promising materials for biomedical devices because of their high mechanical, shape memory, biodegradable, and anti-biofouling properties. These materials are expected to be applied to biomaterials such as embolization materials for aneurysms and a novel type of membrane for postoperative adhesion prevention.

Graphical abstract: Biodegradable shape memory polymers functionalized with anti-biofouling interpenetrating polymer networks

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Supplementary files

Article information


Submitted
15 Jun 2016
Accepted
18 Jul 2016
First published
19 Jul 2016

J. Mater. Chem. B, 2016,4, 5394-5404
Article type
Paper

Biodegradable shape memory polymers functionalized with anti-biofouling interpenetrating polymer networks

I. Dueramae, M. Nishida, T. Nakaji-Hirabayashi, K. Matsumura and H. Kitano, J. Mater. Chem. B, 2016, 4, 5394
DOI: 10.1039/C6TB01478J

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