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Issue 41, 2016
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Nanoparticle delivery systems for siRNA-based therapeutics

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RNA interference (RNAi) is a naturally occurring endogenous regulatory process in which the short double-stranded RNA causes sequence-specific post-transcriptional gene silencing. Small interfering RNA (siRNA) represents great therapeutic potential for diseases (e.g., cancer) caused by abnormal gene overexpression or mutation. The major challenge in using RNAi for disease therapy is the targeted and effective delivery of siRNA in vivo. The development of nanotechnology with the important progress in nanoparticle-mediated delivery systems promises efficient intracellular siRNA delivery. This review summarizes the recent advances in nanoparticle delivery systems for siRNA-based therapeutics.

Graphical abstract: Nanoparticle delivery systems for siRNA-based therapeutics

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Publication details

The article was received on 14 Jun 2016, accepted on 21 Aug 2016 and first published on 22 Aug 2016

Article type: Review Article
DOI: 10.1039/C6TB01462C
Citation: J. Mater. Chem. B, 2016,4, 6620-6639

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    Nanoparticle delivery systems for siRNA-based therapeutics

    J. Li, S. Xue and Z. Mao, J. Mater. Chem. B, 2016, 4, 6620
    DOI: 10.1039/C6TB01462C

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