Issue 40, 2016

Collagen: a network for regenerative medicine


The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation, via fibrillogenesis, can be controlled in vitro by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized via cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.

Graphical abstract: Collagen: a network for regenerative medicine

Article information

Article type
Review Article
31 Mar 2016
20 Aug 2016
First published
22 Aug 2016
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2016,4, 6484-6496

Collagen: a network for regenerative medicine

K. M. Pawelec, S. M. Best and R. E. Cameron, J. Mater. Chem. B, 2016, 4, 6484 DOI: 10.1039/C6TB00807K

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