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Issue 14, 2016
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Surface labeling of enveloped virus with polymeric imidazole ligand-capped quantum dots via the metabolic incorporation of phospholipids into host cells

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Abstract

We report a general method for the preparation of quantum dot-labeled viruses through a strain-promoted azide–alkyne cycloaddition (SPAAC) reaction. The quantum dot sample was functionalized with methacrylate-based polymeric imidazole ligands (MA-PILs) bearing dibenzocyclooctyne groups. Enveloped measles virus was labeled with azide groups through the metabolic incorporation of a choline analogue into the host cell membrane, and then linked with the modified QDs. The virus retained its infectious ability against host cells after the modification with MA-PIL capped QDs.

Graphical abstract: Surface labeling of enveloped virus with polymeric imidazole ligand-capped quantum dots via the metabolic incorporation of phospholipids into host cells

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Supplementary files

Article information


Submitted
29 Jan 2016
Accepted
03 Mar 2016
First published
03 Mar 2016

J. Mater. Chem. B, 2016,4, 2421-2427
Article type
Paper

Surface labeling of enveloped virus with polymeric imidazole ligand-capped quantum dots via the metabolic incorporation of phospholipids into host cells

X. Zhao, Y. Shen, E. A. Adogla, A. Viswanath, R. Tan, B. C. Benicewicz, A. B. Greytak, Y. Lin and Q. Wang, J. Mater. Chem. B, 2016, 4, 2421
DOI: 10.1039/C6TB00263C

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