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Issue 2, 2016
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Functionalised type-I collagen as a hydrogel building block for bio-orthogonal tissue engineering applications

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Abstract

In this study, we derivatized type I collagen without altering its triple helical conformation to allow for facile hydrogel formation via the Michael addition of thiols to methacrylates without the addition of other crosslinking agents. This method provides the flexibility needed for the fabrication of injectable hydrogels or pre-fabricated implantable scaffolds, using the same components by tuning the modulus from Pa to kPa. Enzymatic degradability of the hydrogels can also be easily fine-tuned by variation of the ratio and the type of the cross-linking component. The structural morphology reveals a lamellar structure mimicking native collagen fibrils. The versatility of this material is demonstrated by its use as a pre-fabricated substrate for culturing human corneal epithelial cells and as an injectable hydrogel for 3-D encapsulation of cardiac progenitor cells.

Graphical abstract: Functionalised type-I collagen as a hydrogel building block for bio-orthogonal tissue engineering applications

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Publication details

The article was received on 30 Sep 2015, accepted on 20 Nov 2015 and first published on 23 Nov 2015


Article type: Paper
DOI: 10.1039/C5TB02035B
Citation: J. Mater. Chem. B, 2016,4, 318-326
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    Functionalised type-I collagen as a hydrogel building block for bio-orthogonal tissue engineering applications

    R. Ravichandran, M. M. Islam, E. I. Alarcon, A. Samanta, S. Wang, P. Lundström, J. Hilborn, M. Griffith and J. Phopase, J. Mater. Chem. B, 2016, 4, 318
    DOI: 10.1039/C5TB02035B

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