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Issue 9, 2016
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Biomolecular strategies to modulate the macrophage response to implanted materials

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Abstract

The material-induced foreign body response is a major challenge for implanted medical devices. This review highlights recent developments in biomimetic approaches to create biomaterials that mitigate the host response to biomaterials. Specifically, we will describe strategies in which biomaterials are decorated with endogenously expressed biomolecules that naturally modulate the function of immune cells. These include molecules that directly bind to and interact with immune cells, as well as molecules that control complement activation or thrombosis and indirectly modulate immune cell function. We provide perspective on how these approaches may impact the design of materials for medical devices and tissue engineering.

Graphical abstract: Biomolecular strategies to modulate the macrophage response to implanted materials

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Publication details

The article was received on 07 Aug 2015, accepted on 08 Sep 2015 and first published on 09 Sep 2015


Article type: Review Article
DOI: 10.1039/C5TB01605C
J. Mater. Chem. B, 2016,4, 1600-1609

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    Biomolecular strategies to modulate the macrophage response to implanted materials

    Y. K. Kim, E. Y. Chen and W. F. Liu, J. Mater. Chem. B, 2016, 4, 1600
    DOI: 10.1039/C5TB01605C

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