Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 39, 2016
Previous Article Next Article

Clusters of red blood cells in microcapillary flow: hydrodynamic versus macromolecule induced interaction

Author affiliations

Abstract

We present experiments on RBCs that flow through micro-capillaries under physiological conditions. The strong flow-shape coupling of these deformable objects leads to a rich variety of cluster formation. We show that the RBC clusters form as a subtle imbrication between hydrodynamic interactions and adhesion forces because of plasma proteins, mimicked by the polymer dextran. Clusters form along the capillaries and macromolecule-induced adhesion contributes to their stability. However, at high yet physiological flow velocities, shear stresses overcome part of the adhesion forces, and cluster stabilization due to hydrodynamics becomes stronger. For the case of pure hydrodynamic interaction, cell-to-cell distances have a pronounced bimodal distribution. Our 2D-numerical simulations on vesicles capture the transition between adhesive and non-adhesive clusters at different flow velocities.

Graphical abstract: Clusters of red blood cells in microcapillary flow: hydrodynamic versus macromolecule induced interaction

Back to tab navigation

Article information


Submitted
19 May 2016
Accepted
01 Sep 2016
First published
02 Sep 2016

Soft Matter, 2016,12, 8235-8245
Article type
Paper

Clusters of red blood cells in microcapillary flow: hydrodynamic versus macromolecule induced interaction

V. Clavería, O. Aouane, M. Thiébaud, M. Abkarian, G. Coupier, C. Misbah, T. John and C. Wagner, Soft Matter, 2016, 12, 8235
DOI: 10.1039/C6SM01165A

Social activity

Search articles by author

Spotlight

Advertisements