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Issue 20, 2016
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Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection

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Abstract

The ramification of cationic amphiphiles on their unsaturated lipid chains is readily achieved by using the thiol–ene click reaction triggering the formation of an inverted hexagonal phase (HII). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.

Graphical abstract: Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection

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Publication details

The article was received on 10 Mar 2016, accepted on 22 Apr 2016 and first published on 25 Apr 2016


Article type: Communication
DOI: 10.1039/C6SM00609D
Soft Matter, 2016,12, 4516-4520

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    Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection

    D. Afonso, T. Le Gall, H. Couthon-Gourvès, A. Grélard, S. Prakash, M. Berchel, N. Kervarec, E. J. Dufourc, T. Montier and P. Jaffrès, Soft Matter, 2016, 12, 4516
    DOI: 10.1039/C6SM00609D

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