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Issue 3, 2017
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Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

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Abstract

A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)3 (bpydc = 5,5′-dicarboxylate-2,2′-bipyridine) into a highly robust Zr(IV)-based metal–organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.

Graphical abstract: Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

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Publication details

The article was received on 31 Oct 2016, accepted on 21 Dec 2016 and first published on 21 Dec 2016


Article type: Edge Article
DOI: 10.1039/C6SC04824B
Citation: Chem. Sci., 2017,8, 2381-2386
  • Open access: Creative Commons BY license
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    Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

    S. Diring, A. Carné-Sánchez, J. Zhang, S. Ikemura, C. Kim, H. Inaba, S. Kitagawa and S. Furukawa, Chem. Sci., 2017, 8, 2381
    DOI: 10.1039/C6SC04824B

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