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Issue 3, 2017
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Toward a mild dehydroformylation using base-metal catalysis

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Abstract

Dehydroformylation, or the reaction of aldehydes to produce alkenes, hydrogen gas, and carbon monoxide, is a powerful transformation that is underdeveloped despite the high industrial importance of the reverse reaction, hydroformylation. Interestingly, nature routinely performs a related transformation, oxidative dehydroformylation, in the biosynthesis of cholesterol and related sterols under mild conditions using base-metal catalysts. In contrast, chemists have recently developed a non-oxidative dehydroformylation method; however, it requires high temperatures and a precious-metal catalyst. Careful study of both approaches has informed our efforts to design a base-metal catalyzed, mild dehydroformylation method that incorporates benefits from each while avoiding several of their respective disadvantages. Importantly, we show that cooperative base metal catalysis presents a powerful, mechanistically unique approach to reactions which are difficult to achieve using conventional catalyst design.

Graphical abstract: Toward a mild dehydroformylation using base-metal catalysis

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Publication details

The article was received on 14 Oct 2016, accepted on 08 Nov 2016 and first published on 09 Nov 2016


Article type: Edge Article
DOI: 10.1039/C6SC04607J
Chem. Sci., 2017,8, 1954-1959
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Toward a mild dehydroformylation using base-metal catalysis

    D. J. Abrams, J. G. West and E. J. Sorensen, Chem. Sci., 2017, 8, 1954
    DOI: 10.1039/C6SC04607J

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