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Issue 3, 2017
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Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

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Abstract

The generation of antibody conjugates with a loading of two modules is desirable for a host of reasons. Whilst certain antibody engineering approaches have been useful in the preparation of such constructs, a reliable method based on a native antibody scaffold without the use of enzymes or harsh oxidative conditions has hitherto not been achieved. The use of native antibodies has several advantages in terms of cost, practicality, accessibility, time and overall efficiency. Herein we present a novel, reliable method of furnishing antibody conjugates with a loading of two modules starting from a native antibody scaffold.

Graphical abstract: Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

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Article information


Submitted
15 Aug 2016
Accepted
24 Nov 2016
First published
28 Nov 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 2056-2060
Article type
Edge Article

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

M. T. W. Lee, A. Maruani, D. A. Richards, J. R. Baker, S. Caddick and V. Chudasama, Chem. Sci., 2017, 8, 2056
DOI: 10.1039/C6SC03655D

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