Issue 11, 2016

Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization


Hyperpolarization of metabolites by dissolution dynamic nuclear polarization (D-DNP) for MRI applications often requires fast and efficient removal of the radicals (polarizing agents). Ordered mesoporous SBA-15 silica materials containing homogeneously dispersed radicals, referred to as HYperPolarizing SOlids (HYPSOs), enable high polarization – P(1H) = 50% at 1.2 K – and straightforward separation of the polarizing HYPSO material from the hyperpolarized solution by filtration. However, the one-dimensional tubular pores of SBA-15 type materials are not ideal for nuclear spin diffusion, which may limit efficient polarization. Here, we develop a generation of hyperpolarizing solids based on a SBA-16 structure with a network of pores interconnected in three dimensions, which allows a significant increase of polarization, i.e. P(1H) = 63% at 1.2 K. This result illustrates how one can improve materials by combining a control of the incorporation of radicals with a better design of the porous network structures.

Graphical abstract: Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization

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Article information

Article type
Edge Article
11 May 2016
15 Jul 2016
First published
18 Jul 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 6846-6850

Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization

D. Baudouin, H. A. van Kalkeren, A. Bornet, B. Vuichoud, L. Veyre, M. Cavaillès, M. Schwarzwälder, W.-C. Liao, D. Gajan, G. Bodenhausen, L. Emsley, A. Lesage, S. Jannin, C. Copéret and C. Thieuleux, Chem. Sci., 2016, 7, 6846 DOI: 10.1039/C6SC02055K

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