Issue 112, 2016, Issue in Progress
From the journal:

RSC Advances

Modular supramolecular ureidopyrimidinone polymer carriers for intracellular delivery†

Maarten H. Bakker, ORCID logo ab   Roxanne E. Kieltyka, ORCID logo ab   Lorenzo Albertazzi ORCID logo ab  and  Patricia Y. W. Dankers*abc  

* Corresponding authors

a Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands
E-mail: p.y.w.dankers@tue.nl

b Laboratory of Chemical Biology, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands

c Laboratory for Cell and Tissue Engineering, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands

Abstract

Ureidopyrimidinone-based polymers in solution provide a new platform for intracellular drug delivery. Here we show the synthesis of functional supramolecular polymers by mixing of monomers with various functionalities. Introduction of cationic monomers made them suitable for cellular uptake and siRNA delivery.

Graphical abstract: Modular supramolecular ureidopyrimidinone polymer carriers for intracellular delivery

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Article information

DOI
https://doi.org/10.1039/C6RA22490C
Article type
Communication
Submitted
08 Sep 2016
Accepted
12 Nov 2016
First published
14 Nov 2016

RSC Adv., 2016,6, 110600-110603

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Modular supramolecular ureidopyrimidinone polymer carriers for intracellular delivery

M. H. Bakker, R. E. Kieltyka, L. Albertazzi and P. Y. W. Dankers, RSC Adv., 2016, 6, 110600 DOI: 10.1039/C6RA22490C

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