Jump to main content
Jump to site search

Issue 111, 2016, Issue in Progress
Previous Article Next Article

Dieckol, an edible seaweed polyphenol, retards rotenone-induced neurotoxicity and α-synuclein aggregation in human dopaminergic neuronal cells

Author affiliations

Abstract

Dopaminergic neurons are particularly vulnerable to oxidative stress, which may initiate a cascade of intracellular toxic events that lead to protein aggregation and subsequent cell death, causing Parkinson's disease. Here, we investigate the neuroprotective effect of dieckol, which is a polyphenol isolated from an edible seaweed, Ecklonia cava, on rotenone-induced oxidative stress in SH-SY5Y cells, a human dopaminergic neuronal cell line. Dieckol was found to reduce intracellular reactive oxygen species (ROS) and cytochrome C release induced by treatment with rotenone. Consequently, dieckol reduced rotenone-induced cell death, and retarded rotenone-induced α-synuclein aggregation in α-synuclein-overexpressing SH-SY5Y cells. These results clearly indicate that dieckol possesses prominent antioxidant activity in dopaminergic neuronal cells preventing α-synuclein aggregation. Therefore, it could be a potential therapeutic agent for the prevention of neurodegenerative diseases such as Parkinson's disease.

Graphical abstract: Dieckol, an edible seaweed polyphenol, retards rotenone-induced neurotoxicity and α-synuclein aggregation in human dopaminergic neuronal cells

Back to tab navigation

Supplementary files

Article information


Submitted
30 Aug 2016
Accepted
10 Nov 2016
First published
11 Nov 2016

RSC Adv., 2016,6, 110040-110046
Article type
Paper

Dieckol, an edible seaweed polyphenol, retards rotenone-induced neurotoxicity and α-synuclein aggregation in human dopaminergic neuronal cells

S. Cha, S. Heo, Y. Jeon and S. M. Park, RSC Adv., 2016, 6, 110040
DOI: 10.1039/C6RA21697H

Social activity

Search articles by author

Spotlight

Advertisements