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Issue 96, 2016, Issue in Progress
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Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides

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Abstract

A highly efficient one-pot method for the reductive coupling of indoles to nitrostyrenes in polyphosphoric acid doped with PCl3 was developed. This method allows direct and expeditious access to primary (indol-3-yl)acetamides, interesting as anti-cancer drug candidates.

Graphical abstract: Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides

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Article information


Submitted
25 Aug 2016
Accepted
26 Sep 2016
First published
27 Sep 2016

RSC Adv., 2016,6, 93881-93886
Article type
Paper

Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides

A. V. Aksenov, N. A. Aksenov, Z. V. Dzhandigova, D. A. Aksenov, L. G. Voskressensky, V. G. Nenajdenko and M. Rubin, RSC Adv., 2016, 6, 93881
DOI: 10.1039/C6RA21399E

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