High sensitivity simultaneous determination of myricetin and rutin using a polyfurfural film modified glassy carbon electrode

Abstract

In this work, we successfully develop a simple electrochemical sensor based on a polyfurfural film modified glassy carbon electrode to realize the simultaneous electrochemical determination of myricetin and rutin. The proposed sensor exhibits superior electrocatalytic activity to both myricetin and rutin, simultaneously demonstrating a wide linear detection range of 0.05–10 μmol dm⁻³ with a low detection limit of 10 ± 0.5 nmol dm⁻³ (S/N = 3, α = 0.05, n = 3, type I error) for myricetin, and linear detection range of 0.001–10 μmol dm⁻³ with a low detection limit of 0.025 ± 0.004 nmol dm⁻³ (S/N = 3, α = 0.05, n = 3, type I error) for rutin. With favorable selectivity, stability and reproducibility, the proposed sensor was satisfied by applying for simultaneous determination of myricetin and rutin in real samples. It may provide a new strategy to simultaneously determine different kinds of polyphenolic compounds with polyfurfural film modified glassy carbon electrode in application of pharmaceutical and biological analysis in the future.