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Issue 86, 2016, Issue in Progress
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Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

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Abstract

The Ruppert–Prakash reagent is the most powerful and well-documented reagent for trifluoromethylation. Despite its versatility, no general method exists for its use in a flow system. Here we report the first flow trifluoromethylation of carbonyl compounds and its utility for drug synthesis of efavirenz and HSD-016, including preliminary results of enantioselective variants.

Graphical abstract: Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

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Publication details

The article was received on 05 Aug 2016, accepted on 22 Aug 2016 and first published on 24 Aug 2016


Article type: Communication
DOI: 10.1039/C6RA19790F
RSC Adv., 2016,6, 82716-82720

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    Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

    S. Okusu, K. Hirano, Y. Yasuda, E. Tokunaga and N. Shibata, RSC Adv., 2016, 6, 82716
    DOI: 10.1039/C6RA19790F

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