Direct C–H heteroarylation of azoles with 1,2-di(pyrimidin-2-yl)disulfides through C–S cleavage of disulfides†
Abstract
C–C bond construction via C–H bond functionalization of oxazoles/thiazoles and C–S bond cleavage of di(hetero)aryl disulfides is described. Central to this strategy is the conversion of disulfides into 2-heterocyclic aryl oxazoles or thiazole by palladium-catalyzed copper-promoted chemoselective C–S bond cleavage; the corresponding products were generated in good yields.