Issue 100, 2016, Issue in Progress

Isolation of multiantennary N-glycans from glycoproteins for hepatocyte specific targeting via the asialoglycoprotein receptor

Abstract

The asialoglycoprotein receptor (ASGPR) expressed on parenchymal liver cells specifically binds multivalent carbohydrates from desialylated glycoproteins. This feature offers a huge potential for hepatocyte specific drug targeting. In this study, multiantennary N-glycans from asialofetuin have been isolated to actively target the asialoglycoprotein receptor on human hepatocellular carcinoma cells in vitro.

Graphical abstract: Isolation of multiantennary N-glycans from glycoproteins for hepatocyte specific targeting via the asialoglycoprotein receptor

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2016
Accepted
07 Oct 2016
First published
07 Oct 2016

RSC Adv., 2016,6, 97636-97640

Isolation of multiantennary N-glycans from glycoproteins for hepatocyte specific targeting via the asialoglycoprotein receptor

D. Witzigmann, P. Detampel, F. Porta and J. Huwyler, RSC Adv., 2016, 6, 97636 DOI: 10.1039/C6RA18297F

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