Issue 101, 2016, Issue in Progress
From the journal:

RSC Advances

Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities†

Gang Liu,‡a   Shanshan Song,‡b   Xiaohua Liu,a   Ao Zhang,ac   Zehong Miao*bc  and  Chunyong Ding*a  

* Corresponding authors

a CAS Key Laboratory of Receptor Research, Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
E-mail: chding@simm.ac.cn
Fax: +86-21-50806635
Tel: +86-21-50806035

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
E-mail: zhmiao@simm.ac.cn
Fax: +86-21-50806600
Tel: +86-21-50806820

c University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Two new series of dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) were designed and synthesized though a 1,3-dipolar cycloaddition. Subsequent pharmacological screening led to several compounds having dramatically improved antiproliferative effects against several human tumor cell lines compared to artemisinin and dihydroartemisinin. Mechanistic studies on the most potent artemalogs were investigated.

Graphical abstract: Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities

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Article information

DOI
https://doi.org/10.1039/C6RA17323C
Article type
Paper
Submitted
06 Jul 2016
Accepted
08 Oct 2016
First published
12 Oct 2016

RSC Adv., 2016,6, 98975-98984

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Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities

G. Liu, S. Song, X. Liu, A. Zhang, Z. Miao and C. Ding, RSC Adv., 2016, 6, 98975 DOI: 10.1039/C6RA17323C

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