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Issue 97, 2016
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Combination of gelatin and tranexamic acid offers improved haemostasis and safe use on internal hemorrhage control

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Abstract

Effective hemorrhage control with materials developed by emerging technologies is important in preventing massive bleeding in hospitals, accident sites and battlefields. Various materials have been developed for the treatment of hemorrhage. Gelatin is one, which is commonly used in combination with thrombin. It is generally used in internal bleeding cases owing to its safety, and superior biocompatibility and biodegradability. On the other hand, thrombin the main component that provides rapid haemostasis has drawbacks such as serious disease transmission from donors and high cost. Chitosan is another haemostatic material component with low cost and superior efficiency. However, chitosan-based haemostatic materials are not recommended for internal use. In this paper, we examine the use of a combination of gelatin and tranexamic acid microparticles in internal bleeding control, on the basis of comparative studies both in in vitro and in in vivo conditions. This composite haemostatic material provided rapid haemostasis and biocompatibility, and provided a safe use in internal applications.

Graphical abstract: Combination of gelatin and tranexamic acid offers improved haemostasis and safe use on internal hemorrhage control

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Article information


Submitted
29 Jun 2016
Accepted
20 Sep 2016
First published
28 Sep 2016

RSC Adv., 2016,6, 95189-95198
Article type
Paper

Combination of gelatin and tranexamic acid offers improved haemostasis and safe use on internal hemorrhage control

U. Aydemir Sezer, Z. Kocer, B. Aru, G. Y. Demirel, M. Gulmez, A. Aktekin, S. Ozkara and S. Sezer, RSC Adv., 2016, 6, 95189
DOI: 10.1039/C6RA16790J

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