Synthesis of a phenylboronic acid-functionalized thermosensitive block copolymer and its application in separation and purification of vicinal-diol-containing compounds

Abstract

A phenylboronic acid-functionalized amphiphilic thermosensitive block copolymer was prepared by taking PEO₂₀PPO₆₀PEO₂₀ as the template and a detailed study of its performance in downstream separation processes was presented. Alizarin red was used as the model compound to study the feasibility of using an affinity adsorption system and aqueous two-phase flotation system based on the phenylboronic acid-functionalized PEO₂₀PPO₆₀PEO₂₀ for the separation and purification of ortho-hydroxyl compounds. The optimized conditions of the affinity adsorption experiment were: 2% phenylboronic acid-functionalized PEO₂₀PPO₆₀PEO₂₀, 0.3 mg alizarin red, 40% K₂HPO₄ and 4 h adsorption time. The affinity adsorption rate of alizarin red reached 98% under such conditions. In addition, a flotation recovery of alizarin red of 97% was obtained under the optimal conditions of aqueous two-phase flotation: 0.3 g of collector, 12 g K₂HPO₄, 0.6 mg alizarin red, 15 mL min⁻¹ nitrogen flow rate and 40 min flotation time. Both methods are capable of separating alizarin red, suggesting their broad application prospect in downstream separation engineering of vicinal-diol-containing compounds.