Issue 73, 2016
From the journal:

RSC Advances

DCPO based nanoparticles as a near-infrared fluorescent probe for Cathepsin B†

Bin Bao,a   Yaqian Liu,a   Lei Wanga  and  Wei Lu*ab  

* Corresponding authors

a School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China
E-mail: wlu@chem.ecnu.edu.cn

b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. China

Abstract

A novel NIR fluorescent probe for CTB was designed and synthesized based on DCPO. The newly synthesized probe was quite water-soluble and formed nanoparticles which has potential in tumor-targeted imaging. When treated with CTB, the probe released the fluorescent molecule DCPO. Imaging of different tumor cells also indicated that the probe was efficient in detecting CTB.

Graphical abstract: DCPO based nanoparticles as a near-infrared fluorescent probe for Cathepsin B

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Article information

DOI
https://doi.org/10.1039/C6RA14628G
Article type
Paper
Submitted
06 Jun 2016
Accepted
18 Jul 2016
First published
18 Jul 2016

RSC Adv., 2016,6, 69540-69545

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DCPO based nanoparticles as a near-infrared fluorescent probe for Cathepsin B

B. Bao, Y. Liu, L. Wang and W. Lu, RSC Adv., 2016, 6, 69540 DOI: 10.1039/C6RA14628G

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