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Issue 71, 2016, Issue in Progress
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Encapsulation of curcumin over carbon dot coated TiO2 nanoparticles for pH sensitive enhancement of anticancer and anti-psoriatic potential

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Abstract

The surface engineering of rutile phase TiO2 nanoparticles was performed by carbogenic carbon dots for biological applications. Carbon dots were synthesized by a green hydrothermal method from the ginger herb and TiO2 nanoparticles were synthesized by co-precipitation of TTIP. The carbon dots were successfully coated over the surface of TiO2 nanoparticles and the hydrophobic multi-therapeutic drug curcumin was wet loaded chemically. These nanostructures were characterized using UV-Vis, PL and FTIR spectroscopy and XRD and TEM analysis. The curcumin loaded C dot coated TiO2 nanoparticles have shown higher anticancer potential than unloaded nanoparticles on MCF-7 breast cancer cells and anti-psoriatic potential on HaCaT keratinocyte skin cells. The enhancement in biocompatibility was observed for curcumin after loading on TiO2 nanoparticles, thus destroying the hydrophobicity after C dot surface engineering.

Graphical abstract: Encapsulation of curcumin over carbon dot coated TiO2 nanoparticles for pH sensitive enhancement of anticancer and anti-psoriatic potential

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Article information


Submitted
28 May 2016
Accepted
23 Jun 2016
First published
28 Jun 2016

RSC Adv., 2016,6, 66745-66755
Article type
Paper

Encapsulation of curcumin over carbon dot coated TiO2 nanoparticles for pH sensitive enhancement of anticancer and anti-psoriatic potential

V. J. Sawant, S. R. Bamane, D. G. Kanase, S. B. Patil and J. Ghosh, RSC Adv., 2016, 6, 66745
DOI: 10.1039/C6RA13851A

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