Issue 60, 2016
From the journal:

RSC Advances

Synthesis of substituted γ- and δ-lactams based on titanocene(iii)-catalysed radical cyclisations of trichloroacetamides†

Faïza Diaba,a   Enrique Gómez-Bengoa,b   Juan M. Cuerva,c   Josep Bonjoch*a  and  José Justicia*c  

* Corresponding authors

a Laboratori de Química Orgànica, Facultat de Farmàcia, IBUB, Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain
E-mail: josep.bonjoch@ub.edu

b Departamento de Química Orgánica I, Universidad del País Vasco, Manuel Lardizábal 3, 20018 San Sebastián, Spain

c Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, C. U. Fuentenueva s/n, 18071-Granada, Spain
E-mail: jjusti@ugr.es

Abstract

A new procedure for the synthesis of γ- and δ-lactams based on a Cp2TiCl-catalysed cyclisation of trichloroacetamides under mild reaction conditions is reported. Theoretical studies supported the observed regioselectivity in the cyclisations and the mechanism involved in the dehalogenation process.

Graphical abstract: Synthesis of substituted γ- and δ-lactams based on titanocene(iii)-catalysed radical cyclisations of trichloroacetamides

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Article information

DOI
https://doi.org/10.1039/C6RA12180B
Article type
Communication
Submitted
10 May 2016
Accepted
30 May 2016
First published
01 Jun 2016
This article is Open Access
Creative Commons BY license

RSC Adv., 2016,6, 55360-55365

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Synthesis of substituted γ- and δ-lactams based on titanocene(III)-catalysed radical cyclisations of trichloroacetamides

F. Diaba, E. Gómez-Bengoa, J. M. Cuerva, J. Bonjoch and J. Justicia, RSC Adv., 2016, 6, 55360 DOI: 10.1039/C6RA12180B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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