PEG-SANM nanocomposite: a new catalytic application towards clean and highly efficient Biginelli-like reaction under solvent-free conditions

Abstract

A series of pyrimidinone derivatives were efficiently synthesized using PEG-SANM nanocomposite as the solid acid nanocatalyst under mild and solvent-free conditions. The generality of the process was successfully demonstrated by variation of the starting materials. Also, large-scale synthesis of products occurred readily in the presence of this nanocatalyst. This new method eliminated the use of organic solvents and the products were obtained in good to excellent yields and high purities after a simple workup in short reaction times. No chromatographic separation is needed for isolation of the obtained products. The nanocatalyst was recovered and reused for up to five times without a noticeable decrease in the catalytic activity.