A copper catalyzed multicomponent cascade redox reaction for the synthesis of quinazolinones

Abstract

A copper catalyzed multicomponent cascade redox reaction for the synthesis of various quinazolinones starting from easily available 2-bromobenzamides, benzylic alcohols and sodium azide as a nitrogen source has been developed. The reaction involves copper catalyzed azidation of 2-bromobenzamide via an S_NAr reaction and oxidation of benzyl alcohol followed by sequential reduction–condensation–oxidation to produce quinazolinones.