Issue 61, 2016, Issue in Progress
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RSC Advances

Primaquine-based ionic liquids as a novel class of antimalarial hits†

Ricardo Ferraz,*ab   Joana Noronha,a   Fernanda Murtinheira, ORCID logo c   Fátima Nogueira,c   Marta Machado,d   Miguel Prudêncio,d   Silvia Parapini,e   Sarah D'Alessandro,e   Cátia Teixeira, ORCID logo a   Ana Gomes,a   Cristina Prudênciobf  and  Paula Gomes ORCID logo *a  

* Corresponding authors

a UCIBIO-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal
E-mail: pgomes@fc.up.pt

b Ciências Químicas e das Biomoléculas, CISA, Escola Superior de Tecnologia da Saúde do Porto – Instituto Politécnico do Porto, Rua Valente Perfeito 322, 4400-330 Vila Nova de Gaia, Portugal
E-mail: ricardoferraz@eu.ipp.pt

c Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008 Lisboa, Portugal

d Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Av.Prof. Egas Moniz, 1649-028 Lisboa, Portugal

e Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Pascal, 36 20133 Milano, Italy

f I3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal

Abstract

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

Graphical abstract: Primaquine-based ionic liquids as a novel class of antimalarial hits

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Article information

DOI
https://doi.org/10.1039/C6RA10759A
Article type
Communication
Submitted
26 Apr 2016
Accepted
06 Jun 2016
First published
07 Jun 2016

RSC Adv., 2016,6, 56134-56138

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Primaquine-based ionic liquids as a novel class of antimalarial hits

R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado, M. Prudêncio, S. Parapini, S. D'Alessandro, C. Teixeira, A. Gomes, C. Prudêncio and P. Gomes, RSC Adv., 2016, 6, 56134 DOI: 10.1039/C6RA10759A

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