Issue 54, 2016, Issue in Progress
From the journal:

RSC Advances

Synthesis of 2-trifluoromethylquinolines via copper-mediated intramolecular oxidative cyclization of N-(2-alkenylaryl) enamines†

Wenfan Chen,a   Qiuping Ding,*a   Ziyi Niea  and  Yiyuan Peng*a  

* Corresponding authors

a Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of Green Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, China
E-mail: dqpjxnu@gmail.com, yypeng@jxnu.edu.cn

Abstract

A general and efficient copper-mediated intramolecular oxidative cyclization of N-(2-alkenylaryl) enamines for the synthesis of 2-trifluoromethylquinolines has been developed. The targeted heterocycle is a privileged structure in many natural compounds and drugs with a broad range of biological activities.

Graphical abstract: Synthesis of 2-trifluoromethylquinolines via copper-mediated intramolecular oxidative cyclization of N-(2-alkenylaryl) enamines

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Article information

DOI
https://doi.org/10.1039/C6RA09741C
Article type
Paper
Submitted
15 Apr 2016
Accepted
12 May 2016
First published
12 May 2016

RSC Adv., 2016,6, 48767-48773

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Synthesis of 2-trifluoromethylquinolines via copper-mediated intramolecular oxidative cyclization of N-(2-alkenylaryl) enamines

W. Chen, Q. Ding, Z. Nie and Y. Peng, RSC Adv., 2016, 6, 48767 DOI: 10.1039/C6RA09741C

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