Issue 52, 2016

Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

Abstract

A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within the European Lead Factory (ELF) Consortium.

Graphical abstract: Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2016
Accepted
02 May 2016
First published
05 May 2016
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2016,6, 46654-46657

Author version available

Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

P. Wu, M. Å. Petersen, R. Petersen, T. Flagstad, R. Guilleux, M. Ohsten, R. Morgentin, T. E. Nielsen and M. H. Clausen, RSC Adv., 2016, 6, 46654 DOI: 10.1039/C6RA08786H

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