Methylation on CpG repeats modulates hydroxymethylcytosine induced duplex destabilization†
Abstract
Thermodynamic stability of hydroxymethylcytosine (hmC) containing CpG repeats showed that though hmC destabilizes hypomethylated CpG, this effect can be reversed in a heavily methylated duplex. This dual-epigenetic modulation on duplex stability was also observed in cellular-mimic crowding conditions for both A-form DNA–RNA hybrids and B-form DNA–DNA duplexes.