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Issue 62, 2016
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A facile and efficient method for the synthesis of 1,2,4-trisubstituted imidazoles with enamides and benzylamines

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Abstract

A novel and practical method for the construction of 1,2,4-trisubstituted imidazoles with enamides and benzylamines catalysed by CuBr and I2 has been developed. This sustainable, simple and environmentally-friendly procedure tolerates various functional groups and affords a series of trisubstitued imidazoles.

Graphical abstract: A facile and efficient method for the synthesis of 1,2,4-trisubstituted imidazoles with enamides and benzylamines

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Publication details

The article was received on 30 Mar 2016, accepted on 08 Jun 2016 and first published on 08 Jun 2016


Article type: Communication
DOI: 10.1039/C6RA08174F
RSC Adv., 2016,6, 57232-57235

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    A facile and efficient method for the synthesis of 1,2,4-trisubstituted imidazoles with enamides and benzylamines

    J. Cao, X. Zhou, H. Ma, C. Shi and G. Huang, RSC Adv., 2016, 6, 57232
    DOI: 10.1039/C6RA08174F

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