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Issue 48, 2016, Issue in Progress
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Synthesis of 2-hydroxymalonic acid derivatives via tandem oxidation and rearrangement by photo organic catalysis

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Abstract

This report describes a mild method for the direct transformation of β-oxoesters to the corresponding 2-hydroxymalonic esters, tartronic esters, using singlet oxygen produced by a catalytic amount of methylene blue and visible light irradiation using fluorescent lamps. In addition, β-oxoamides were also converted to the corresponding 2-hydroxymalonic ester amides.

Graphical abstract: Synthesis of 2-hydroxymalonic acid derivatives via tandem oxidation and rearrangement by photo organic catalysis

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Article information


Submitted
17 Mar 2016
Accepted
21 Apr 2016
First published
25 Apr 2016

RSC Adv., 2016,6, 42596-42599
Article type
Communication

Synthesis of 2-hydroxymalonic acid derivatives via tandem oxidation and rearrangement by photo organic catalysis

A. Okada, Y. Nagasawa, T. Yamaguchi, E. Yamaguchi, N. Tada, T. Miura and A. Itoh, RSC Adv., 2016, 6, 42596
DOI: 10.1039/C6RA07084A

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