Issue 48, 2016, Issue in Progress
From the journal:

RSC Advances

Synthesis of 2-hydroxymalonic acid derivatives via tandem oxidation and rearrangement by photo organic catalysis†

Akifumi Okada,a   Yoshitomo Nagasawa,a   Tomoaki Yamaguchi,a   Eiji Yamaguchi,a   Norihiro Tada,a   Tsuyoshi Miurab  and  Akichika Itoh*a  

* Corresponding authors

a Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan
E-mail: itoha@gifu-pu.ac.jp
Fax: +81-58-230-8108

b Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
E-mail: tmiura@toyaku.ac.jp
Fax: +81-42-676-4479
Tel: +81-42-676-4479

Abstract

This report describes a mild method for the direct transformation of β-oxoesters to the corresponding 2-hydroxymalonic esters, tartronic esters, using singlet oxygen produced by a catalytic amount of methylene blue and visible light irradiation using fluorescent lamps. In addition, β-oxoamides were also converted to the corresponding 2-hydroxymalonic ester amides.

Graphical abstract: Synthesis of 2-hydroxymalonic acid derivatives via tandem oxidation and rearrangement by photo organic catalysis

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Article information

DOI
https://doi.org/10.1039/C6RA07084A
Article type
Communication
Submitted
17 Mar 2016
Accepted
21 Apr 2016
First published
25 Apr 2016

RSC Adv., 2016,6, 42596-42599

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Synthesis of 2-hydroxymalonic acid derivatives via tandem oxidation and rearrangement by photo organic catalysis

A. Okada, Y. Nagasawa, T. Yamaguchi, E. Yamaguchi, N. Tada, T. Miura and A. Itoh, RSC Adv., 2016, 6, 42596 DOI: 10.1039/C6RA07084A

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