Jump to main content
Jump to site search

Issue 52, 2016

Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate

Author affiliations

Abstract

Cell surface heparan sulfate (HS) represents a common link that many sexually transmitted infections (STIs) require for infection. The role of HS is associated with several viral STIs, which include those caused by herpes simplex virus (HVS), human immunodeficiency virus (HIV), human papillomavirus (HPV) and hepatitis C virus (HCV). Nowadays, no cure has been found for any of the STIs associated with viral pathogens. In this review, we evaluate dendrimers such as peptide derivatized-dendrimers, carbosilane dendrimers, polysulfated galactose functionalized glycodendrimers and PAMAM dendrimers, among others, as potential candidates for the development of topical microbicides against viral STIs associated with HS. Subsequently, we propose the mechanism of action of these dendrimers and how it might be associated with the relevance of HS in several STIs. HS in just an ancillary factor in the case of HIV-1 infection and it plays a major role in the case of HCV, HSV-2 and HPV viruses. However, the mechanism of action presented by these dendrimers is common in all pathologies, acting at the level of viral entry into the target cell, either directly blocking the viral particles that are meant to bind to the HS or binding to cellular co-receptors.

Graphical abstract: Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate

Article information


Submitted
16 Mar 2016
Accepted
19 Apr 2016
First published
20 Apr 2016

RSC Adv., 2016,6, 46755-46764
Article type
Review Article

Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate

R. Ceña-Díez, D. Sepúlveda-Crespo, M. Maly and M. A. Muñoz-Fernández, RSC Adv., 2016, 6, 46755 DOI: 10.1039/C6RA06969J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements