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Issue 48, 2016, Issue in Progress
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Recent developments in multicomponent synthesis of structurally diversified tetrahydropyridines

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Abstract

Tetrahydropyridines (THPDs) have been recognized as a major constituent of naturally occurring alkaloids. Being heterocyclic nitrogenous compounds, they therefore display robust biological and pharmacological profiles. In this context, they are fascinating synthetic targets in synthetic chemistry and as a consequence of this their synthesis through simple and convenient tactics has emerged as an important and challenging task. To meet such challenge, multicomponent reactions (MCRs) are employed as an excellent tool for achieving compounds containing complex diversity in single step and production of their vast libraries. This review represents the advancement made in the field of multicomponent synthesis of THPDs and their derivatives of the last few years.

Graphical abstract: Recent developments in multicomponent synthesis of structurally diversified tetrahydropyridines

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Article information


Submitted
14 Mar 2016
Accepted
11 Apr 2016
First published
27 Apr 2016

RSC Adv., 2016,6, 42045-42061
Article type
Review Article

Recent developments in multicomponent synthesis of structurally diversified tetrahydropyridines

Md. M. Khan, S. Khan, Saigal and S. Iqbal, RSC Adv., 2016, 6, 42045
DOI: 10.1039/C6RA06767K

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