A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity

M. Cuccioloni; L. Bonfili; M. Mozzicafreddo; V. Cecarini; R. Pettinari; F. Condello; C. Pettinari; F. Marchetti; M. Angeletti; A. M. Eleuteri

doi:10.1039/C6RA06403E

A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity

M. Cuccioloni,*^a L. Bonfili,^a M. Mozzicafreddo,^a V. Cecarini,^a R. Pettinari,^b F. Condello,^b C. Pettinari,^b F. Marchetti,^c M. Angeletti^a and A. M. Eleuteri

^a

Author affiliations

* Corresponding authors

^a School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC, Italy
E-mail: massimiliano.cuccioloni@unicam.it

^b School of Pharmacy, University of Camerino, Italy

^c School of Science and Technology, University of Camerino, Italy

Abstract

A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.

RSC Advances

A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity

Abstract

Article information

Download Citation

Permissions

A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity

Social activity

Search articles by author

Spotlight

Advertisements