Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 39, 2016, Issue in Progress

p-tert-Butylthiacalix[4]arenes equipped with guanidinium fragments: aggregation, cytotoxicity, and DNA binding abilities

Author affiliations

Abstract

Mono-, di- and tetracationic thiacalix[4]arenes in a 1,3-alternate conformation functionalized with guanidinium groups showed a strong dependence of the aggregation properties with the ratio of guanidinium/n-decyl fragments attached to phenolic groups. Increasing the amount of guanidinium fragments improved the macrocycles solubility in water as well as the sorption capacity towards polynucleotide molecules. The synthesized thiacalixarenes showed relatively high toxicity comparable with that for similar receptors based on the classical calixarene.

Graphical abstract: p-tert-Butylthiacalix[4]arenes equipped with guanidinium fragments: aggregation, cytotoxicity, and DNA binding abilities

Supplementary files

Article information


Submitted
22 Feb 2016
Accepted
16 Mar 2016
First published
21 Mar 2016

RSC Adv., 2016,6, 32722-32726
Article type
Paper
Author version available

p-tert-Butylthiacalix[4]arenes equipped with guanidinium fragments: aggregation, cytotoxicity, and DNA binding abilities

A. Galukhin, I. Imatdinov and Y. Osin, RSC Adv., 2016, 6, 32722 DOI: 10.1039/C6RA04733E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements