Porous anatase TiO2 derived from a titanium metal–organic framework as a multifunctional phospho-oriented nanoreactor integrating accelerated digestion of proteins and in situ enrichment

Abstract

In this work, hierarchical porous anatase TiO₂ was obtained through hydrolysis and thermal decomposition of a titanium metal–organic framework. With the as-synthesized multifunctional nanoreactor, direct and in situ enrichment of phosphopeptides from undigested phosphorylated proteins could be accomplished in one pot and in a single step within 40 min.