Novel micellar form of poplar propolis with high cytotoxic activity†
Abstract
A novel micellar form of propolis based on a biocompatible poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) block copolymer (PEO26PPO40PEO26) is developed. Beneficially, all biologically active lipophilic constituents of propolis are solubilized with the aid of polymeric micelles in aqueous media. The micellar form of the propolis exhibits high in vitro cytotoxicity at relatively low concentrations.